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Updated: Jan 9, 2026

In vitro Cell Migration and Invasion Assays

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

化学基因连接体2:超越化疗作用 - - 在瘤进展中发挥多方面的作用

Yeying Jin^1,2, Yixuan Wang^1,2, Rui Yang¹

¹Department of Breast Surgery, Shanxi Cancer Hospital/Chinese Academy of Medical Sciences Cancer Hospital Shanxi Hospital/Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan, China.

Frontiers in immunology

|December 4, 2025

概括

化学因子连接体2 (CCL2) 通过调节瘤微环境,促进瘤的生长,进展和转移. 准CCL2为精确的癌症疗法提供了潜力,但需要了解其复杂的监管网络.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

化学因子连接体2 (CCL2) 是瘤微环境 (TME) 中的一个关键调节器.
通过复杂的机制,CCL2影响瘤的发生,进展和转移.
理解CCL2的作用对于开发有效的癌症疗法至关重要.

研究的目的:

系统地审查CCL2在瘤中的产生,调节和多种影响.
阐明CCL2参与癌症的复杂机制.
为基于CCL2的向癌症疗法提供理论基础.

主要方法:

对TME中CCL2生产和调节的系统文献综述.
对CCL2对癌细胞,免疫细胞和转移的影响的分析.
审查当前的临床试验数据和未来的治疗策略.

主要成果:

CCL2由瘤和脑膜细胞连续产生,其表达受到转录因子 (NF-κB,STAT3,AP-1),SNP和表观遗传修饰的调节.
炎症因素和缺氧放大了CCL2分泌,创造了积极的反循环.
通过招募特定的细胞,CCL2促进癌细胞的增殖,迁移,EMT和免疫抑制,同时也通过血管生成和矩阵金属蛋白酶活性驱动侵袭和转移.

结论:

针对CCL2-CCR2轴的目标显示出希望,但由于CCL2冗余和交叉通话,面临限制.
需要对CCL2复杂机制进行进一步的研究.
综合策略,包括miRNA和表观遗传干预,是有效,精确的向治疗的必要条件.

关键词:

化学因子连接体2 化学因子连接体2 免疫细胞免疫细胞免疫瘤学免疫瘤学有针对性的治疗.瘤转移的发生.瘤微环境是一个微环境.

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