通过电话会议和承诺合同 (ERUTECC) 加强招聘:在EFFECTS试验中,一个阶梯子集群随机试验
Eva Isaksson1, Per Näsman2, Per Wester1,3
1Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden.
Upsala journal of medical sciences
|December 4, 2025
概括
一个电话会议干预改善了fluoxetine的效率的招聘 - 一个随机对照性中风试验 (EFFECTS) 研究. 虽然最初的招募人数增加了,但效果是短暂的,这表明为了获得持续的收益,需要重复干预.
科学领域:
- 临床试验 临床试验
- 脑卒中恢复研究研究
- 医疗保健服务研究 医疗服务研究
背景情况:
- 许多随机对照试验 (RCT) 无法达到招聘目标,影响研究时间表和结果.
- 关于弗洛西丁疗效的招募 - - 一项随机对照性中风试验 (EFFECTS) 研究比预期的要慢.
- 需要有效的策略来加强在临床试验中招募参与者.
研究的目的:
- 评估电话会议干预措施在改善EFFECTS试验招聘方面的有效性.
- 评估结构化干预对参加中风康复研究的参与者招募的影响.
主要方法:
- 采用了一个阶梯形,集群随机化研究设计.
- 20个中低招聘中心参与了这项活动,并连续接收电话会议干预.
- 招募率在60天的干预前后进行了比较,并对30天的探索性分析进行了比较.
主要成果:
- 在干预后60天观察到招募率增加了10%.
- 在最初的30天内,招聘率短暂增加了23%.
- 该干预措施在招聘率较低,规模较小和非大学医院的影响更大.
结论:
- 电话会议干预可以暂时促进临床试验的招聘.
- 对招聘的积极影响是暂时的,表明需要重复干预.
- 针对性干预在特定类型的临床试验场所可能最有效.
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