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Updated: Jan 9, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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循环工程提高了主要编辑效率

Bailun Li1,2,3, Zhike Lu2,3,4, Ting Zhou1,2,3

  • 1College of Life Sciences, Zhejiang University, Hangzhou 310058, China.

Molecular therapy. Nucleic acids
|December 4, 2025
PubMed
概括

研究人员通过优化原始编辑部位 (PBS) 和反转录模板 (RTT) 序列,提高了原始编辑 (PE) 的效率. 在pegRNA中添加一个额外的PBS-RTT副本显著提高了编辑结果,增强了PE的PE.

关键词:
MT:RNA/DNA编辑 编辑这是PBS-RTTTT.当地度局部度RNA pegRNA 是一个主编辑主要编辑.固态障碍物 固态障碍物

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