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在前列腺癌成像中,ADC和ADC比率在格里森得分7的区别中进行了ADC和ADC比较评估

D Samaras¹, G Agrotis², D Tsivaka¹

¹Medical Physics Department, Faculty of Medicine, University of Thessaly, 41500 Larissa, Greece.

European journal of radiology open

|December 4, 2025

概括

表面扩散系数比率 (ADCratio) 有效地区分前列腺癌格里森得分7个子组在3.0T的MRI. 这种成像生物标志物显示出可靠的癌症分级的前景.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

多参数MRI (mpMRI) 与扩散权重成像 (DWI) 对于前列腺癌 (PCa) 检测和分级至关重要.
显微扩散系数 (ADC) 有助于组织特征,可能区分格里森得分7 (GS 7) 子组 (GS 3+4 vs. GS 4+3).

研究的目的:

在区分GS 7PCa子组时评估平均ADC和ADC比率.
评估磁场强度 (1.5T与3.0T) 对这些指标诊断性能的影响.

主要方法:

在48名GS 7 PCa患者的回顾性分析中,他们接受了1.5T或3.0T的mpMRI.
独立放射科医生对瘤和正常感兴趣区域 (ROI) 的划定.
统计分析包括观察者间协议 (ICC),相关性,t测试和ROC分析.

主要成果:

对于平均ADC和ADC比率 (ICC > 0.9) 的观测者间非常好的协议.
在3.0T时,平均ADC和ADC比均显著差异化GS 3+4与GS 4+3 (p <0.05).
在1.5T时没有观察到任何显著的差异;然而,在组合数据集中,ADC比率显示出更好的性能 (AUC 0.748) 比平均ADC (AUC 0.718).

结论:

在不同的磁场强度中,ADC比率显示出高可重现性和稳定的诊断性能.
ADC比率显示出作为前列腺癌分级的可靠成像生物标志物的潜力,特别是在3.0T的MRI.

关键词:

这是一个ADCADC ADC.在ADC比率上,ADC比率是什么?扩散加权成像是一种扩散加权成像技术.格里森得分格里森得分多参数核磁共振成像前列腺癌是前列腺癌.

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