侵袭性Talaromyces marneffei真菌病在患有T型淋巴细胞白血病的HIV阴性患者中:病例报告和对新出现风险的审查
Lili Zhan1, Qun Wang1, Xiaoyu Zhang1
1Department of Clinical Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong, People's Republic of China.
Infection and drug resistance
|December 4, 2025
概括
塔拉罗米切斯马尔内菲感染发生在非艾滋病毒免疫受损患者中,包括那些患有血液恶性瘤的患者. 沃里科纳是当安福特里辛B无法获得时的有效治疗方法.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 塔拉罗米塞斯马尔内菲 (Talaromyces marneffei) 是一种通常与艾滋病毒相关的免疫抑制相关的真菌.
- 越来越多地,T. marneffei感染在患有血液恶性瘤的HIV阴性个体中被报告,特别是那些接受新型免疫抑制治疗的人.
研究的目的:
- 在患有T型多淋巴细胞白血病的HIV阴性患者中报告传播的T. marneffei感染病例.
- 审查非艾滋病毒免疫受损宿主中的T. marneffei感染,并确定共同特征和治疗策略.
主要方法:
- 描述了一例传播的T. marneffei感染病例,该病例发生在接受化疗和向治疗的55岁T型多淋巴细胞白血病妇女身上.
- 血液培养,双相形态和内部转录间隔器 (ITS) 测序用于诊断.
- 对10个已发表的T. marneffei病例进行了审查,这些病例发生在非艾滋病毒免疫受损的宿主身上.
主要成果:
- 患者出现了发烧,全细胞减肥和全身感染迹象.
- 通过血液培养和分子方法确认了T. marneffei的存在.
- 由于安福特里辛B不存在,因此获得了沃里康纳治疗的成功,导致了快速的临床改善和负面的后续培养.
结论:
- T. marneffei可以在非艾滋病毒免疫受损的宿主中引起侵入性感染,包括那些患有血液恶性瘤的宿主.
- 常见的特征包括中性质减退,激酶抑制剂的使用,以及诊断延迟.
- 早期的真菌培养,特定阶段的形态学,以及作为替代疗法的沃里可纳对于改善结果至关重要.
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