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周围血液自身干细胞移植中的MRD污染:对复发和多发性骨髓瘤的预后的影响

Jintao Lin¹, Jingsong He¹, Zhen Cai¹

¹Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Leukemia & lymphoma

|December 4, 2025

概括

在多发性骨髓瘤 (MM) 患者的干细胞移植中检测到克隆性血细胞 (CPC) 表明剩余瘤负担. 虽然不是复发的主要原因,但移植中的MRD是一种负面的预后因素,可以指导早期干预策略.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

通过各种方法检测外围血液自身干细胞移植中的克隆性血细胞 (CPC).
检测CPC反映了多发性骨髓瘤 (MM) 患者的残留瘤负担在自主干细胞移植前 (ASCT).

研究的目的:

评估在接受ASCT的MM患者的干细胞移植中最小残留疾病 (MRD) 的预后意义.
探索在移植中检测MRD的实用性,作为综合评估框架内的额外的风险因素.

主要方法:

流动细胞计量流动细胞计量
下一代测序 (NGS) 是指下一代的测序.
下一代流动细胞计 (NGF)

主要成果:

在干细胞移植中检测到MRD是一种负面的预后因素,降低了整体存活率.
移植中MRD污染并不是导致疾病复发的主要原因.
移植中MRD状态可以作为一个强大的额外风险因素.

结论:

对于MRD阳性,高风险患者,早期干预策略 (预防性,密集性或维持性治疗) 可能会改善临床结果.
将移植中的MRD纳入动态评估框架可以提高ASCT接受MM患者的风险分层.

关键词:

多发性骨髓瘤是一种多发性骨髓瘤.克隆性血细胞是一种克隆性血细胞.流动细胞计量是流动细胞计量的方法.最少残留疾病的最小残留疾病.干细胞移植干细胞移植

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