患有慢性前列腺炎/慢性骨盆疼痛综合征的患者抑郁症的风险模型:一个回顾性横截面研究
Cheng Shen1, Yuanfei Ji1, Wei Zhang1
1Department of Urology, Affiliated Hospital 2 of Nantong University, China.
The Journal of international medical research
|December 4, 2025
概括
一个新的预测模型有助于识别患有慢性前列腺炎/慢性骨盆疼痛综合征的患者,这些患者有患抑郁症的高风险. 这种工具有助于早期干预和改善患者的生活质量.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 精神病学是一个精神病学.
- 医疗信息学 医疗信息学
背景情况:
- 慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 经常与抑郁症有关.
- 在确定CP/CPPS患者抑郁风险的预测模型中存在重大差距.
研究的目的:
- 开发和验证一个预测模型来评估诊断为CP/CPPS的患者的抑郁风险.
- 在这个患者群体中确定抑郁症的关键预测因素.
主要方法:
- 一项前性研究涉及599名CP/CPPS患者,分为培训 (n=419) 和验证 (n=180) 队列.
- 使用Boruta和LASSO特征选择构建了一个名图,然后进行多变量逻辑回归.
- 用ROC分析,校准图表和决策曲线分析来评估模型性能.
主要成果:
- 开发的诺米图集成了七个临床预测因素:前列腺进展,高血压,国际前列腺症状评分,睡眠障碍,白细胞计数,甘油三和血红蛋白水平.
- 诺米图表表现出了出色的预测性能,在培训队列中AUC为0.864,在验证队列中为0.911.
结论:
- 验证的诺米图为泌尿科医生提供了一种实用的工具,以识别患有抑郁症高风险的CP/CPPS患者.
- 早期识别有助于及时进行心理干预,有可能改善患者的治疗结果和生活质量.
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