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睡眠宏观结构,循环交替模式和CSF细胞因子在De Novo复发性复发性硬化症:一个受控的多重睡眠研究

A Romigi^1,2, M Stampanoni Bassi^1,3, M Caccamo¹

¹IRCCS Neuromed Istituto Neurologico Mediterraneo, Pozzilli, Italy.

Journal of sleep research

|December 4, 2025

概括

与健康个体相比,多发性硬化症患者表现出碎片化睡眠和改变睡眠架构. 促炎性细胞因子可能会影响睡眠模式,突出显示在治疗多发性硬化症时需要进行睡眠质量评估.

科学领域:

神经学神经学
睡眠医学睡眠医学
免疫学免疫学免疫学

背景情况:

睡眠障碍在多发性硬化症 (MS) 中很常见.
了解早期多发性硬化症的睡眠障碍对于管理至关重要.
在新的患者中需要客观和主观的睡眠评估.

研究的目的:

为了比较 de novo复发性缓解性多发性硬化症患者的客观和主观睡眠参数,与健康对照对比.
研究大脑脊髓液 (CSF) 中的细胞因子与睡眠变化之间的相关性.
探索阻塞性睡眠呼吸暂停 (OSA) 对MS患者睡眠的影响.

主要方法:

在21名新发性多发性硬化患者和21名健康对照者 (HCs) 上进行了夜间多发性睡眠和睡眠质量评估.
在MS患者身上进行了CSF细胞因子分析.
分析了睡眠宏观结构和循环交替模式 (CAP).

主要成果:

多发性硬化患者的睡眠周期时间增加,床上的时间增加,REM睡眠延迟,N3睡眠百分比增加,睡眠开始后的清醒.
与HC相比,MS患者的睡眠效率和REM睡眠百分比降低.
在患有OSA的MS患者中,睡眠变化更为明显.
增加的CAP时间和速度,特别是A3指数和A阶段持续时间,表明睡眠碎片化.
IL-1β与较长的B期持续时间相关,IL-15与A3平均持续时间相关.
疲劳与A1平均持续时间和周期平均持续时间有负相关性.

结论:

新发性复发性复发性复发性多发性硬化与显著的睡眠碎片化有关.
阻塞性睡眠呼吸暂停会加剧MS患者的睡眠障碍.
促炎性细胞因子 (IL-1β,IL-15) 可能调节MS患者的睡眠结构.
解决睡眠质量问题对于综合性多发性硬化症管理至关重要.

关键词:

周期性交替模式的周期性交替模式细胞因子细胞因子多发性硬化症多发性硬化症聚类人体图像 (polysomnography) 是一种多人体图像.睡眠睡眠睡眠睡眠睡眠

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