一项关于历史抵押贷款歧视和当今可行性的预构想队列研究
Sharonda M Lovett1, Lauren A Wise1, Andrea S Richardson2
1Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States.
American journal of epidemiology
|December 4, 2025
概括
从历史上看,红线区是种族主义贷款的遗产,与生育能力的适度下降有关,即每周期的受孕概率. 这项研究分析了美国女性.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 健康的社会决定因素
背景情况:
- 红线,一种歧视性的美国抵押贷款贷款实践,创造了持久的社区差异.
- 历史上的红线对生殖结果的长期健康影响仍未得到充分研究.
研究的目的:
- 估计历史红线 (邻里抵押贷款贷款等级) 和生育能力之间的关联.
- 调查当前居住在历史上红线或衰退的社区是否会影响怀孕概率.
主要方法:
- 1901名美国女性 (21-45岁) 的前性队列研究,在在线妊娠研究 (PRESTO) 队列 (2013-2023).
- 将参与者的住宅地址链接到1930年代的房屋所有者贷款公司 (HOLC) 社区等级 (A/B,C,D/红线).
- 使用比例概率回归来估计生育率 (FRs),对共变量进行调整.
主要成果:
- 显著比例的参与者生活在具有更高风险的HOLC等级 (47.1%的C等级,21.7%的D等级) 的社区.
- 与评分为A/B的社区相比,居住在C级社区的居民的生育率 (FR) 为0.91 (95% CI,0.81-1.03).
- 居住在D级 (红线) 社区与0.86 (95% CI,0.74-1.00) 的FR有关,这表明生育能力有所下降.
结论:
- 当前居住在历史上被减少或下降的社区与适度降低生育能力有关.
- 这些发现凸显了历史上的种族主义住房政策对生殖健康的持续影响.
- 需要进一步的研究来了解将红线与降低生育能力联系在一起的机制.
更多相关视频
06:11Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
Published on: May 17, 2024
1.0K
05:55Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
Published on: June 17, 2025
734
相关概念视频
Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
Infertility in Males
512
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
512
Regression Toward the Mean
6.8K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.8K
Nondisjunction
4.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.8K
Oogenesis
68.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.8K
Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
