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Updated: Jan 6, 2026

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泰特-斯坦:时间到事件简单的毒性和疗效间隔设计,以加速I/II期试验

Hao Sun1, Jieqi Tu2, Revathi Ananthakrishnan1

  • 1Global Biometrics & Data Sciences, Bristol Myers Squibb, Lawrenceville, NJ, USA.

Journal of biopharmaceutical statistics
|December 4, 2025
PubMed
概括

泰特-斯坦是一种新的瘤学试验设计,通过结合毒性和疗效的时间到事件数据来加快剂量发现. 这种适应性设计改善了最佳的生物剂量选择和患者安全.

关键词:
剂量检测方法 剂量检测方法剂量优化剂量优化时间间隔设计设计间隔设计.晚期开始的结果.模型辅助设计模型辅助设计最佳的生物剂量选择和验证.

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