基于生理便机制的生物人工门关节的进展
Minghui Wang1,2, Yarong Zhang1,2, Yucheng Liao1,2
1Institute of Rehabilitation Engineering and Technology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Tissue engineering. Part B, Reviews
|December 4, 2025
概括
人工关节 (AAS) 可以治疗便失禁 (FI),但由于生物机械适合性差,通常会失败. 通过考虑组织相互作用来改进设备设计是提高AAS有效性和寿命的关键.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 重建性手术是一种重建性手术.
背景情况:
- 便失禁 (FI) 显著影响患者的生活质量.
- 人工关节 (AAS) 是严重FI的外科选择.
- 目前的AAS由于与宿主组织的生物机械不相容而面临限制.
研究的目的:
- 审查生物AAS设计的排便生理学.
- 为了分类和比较现有的AAS设备类型.
- 确定AAS的生物机械挑战和未来优化策略.
主要方法:
- 对生理 defecation 机制的审查.
- 将AAS分为角度调节和直接阻塞类型.
- 对每个AAS类型的生物机械故障模式进行比较分析.
主要成果:
- 调节角度的AAS可以导致组织增生.
- 直接封闭的AAS存在组织侵蚀,感染和压力破坏的风险.
- 生物机械不兼容是AAS并发症的主要原因.
结论:
- 协调机械功能与生物环境对于AAS的安全性和有效性至关重要.
- 像恒定力机制和智能传感/人工智能集成等新型设计是有希望的.
- 整合组织工程的生物混合设计可能为AAS提供优越的长期整合.
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