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Updated: Jan 9, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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选择性激活GPCRs:分子动力学显示Siponimod结合,但未能激活S1PR2,与S1PR1不同

Kumari Soniya1, Kruthika Avadhani1, Chanukya Nanduru1

  • 1Computational Chemistry Department, Aganitha.ai, 512T, Road number 29, Jubilee Hills, Hyderabad, Telangana 500033, India.

Journal of chemical information and modeling
|December 4, 2025
PubMed
概括

西波尼莫德通过改变受体动态来选择性地准S1PR1而不是S1PR2. 分子动力学模拟揭示了Siponimodod 的存在.

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