动脉瘤形成,生长和破裂中的表观遗传机制:系统性审查
Oleg Shekhtman1, Irina-Mihaela Matache2, Georgios S Sioutas1
1Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
概括
包括微RNA和DNA甲基化在内的表观遗传修饰越来越被认为是内动脉瘤 (IA) 发展的关键. 需要使用标准化方法进行进一步的研究,以探索这些有前途的治疗点.
科学领域:
- 血管生物学 血管生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
背景情况:
- 内动脉瘤 (IAs) 影响全球3.2%,破裂导致显著的死亡率.
- 遗传因素仅解释了AI遗传性的41%,突出显示了其他机制的作用.
- 表观遗传修饰 (DNA甲基化,基因质修饰,非编码RNA) 影响血管重塑和基因环境相互作用.
研究的目的:
- 系统地审查和综合有关IA发展,进展和破裂中的表观遗传机制的当前文献.
- 为了确定关键的表观遗传途径和IA病原性中涉及的目标.
- 评估IA的表观遗传学研究中的异质性和标准化需求.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 包括PubMed在2023年11月之前的体外和体内研究.
- 选了1019项研究,其中77项符合数据提取的条件.
主要成果:
- 微RNA (59.7%) 和DNA/RNA甲基化 (20.8%) 是研究最多的表观遗传机制.
- 还研究了循环RNAs (7.8%),长非编码RNAs (6.5%) 和基因素修饰 (5.2%).
- 只有三个重叠的表观遗传标被确定,这表明了显著的方法异质性.
结论:
- 表观遗传学研究为内动脉瘤病原体提供了新的见解.
- 跨研究的有限可重现性需要标准化的方法和更大的队列.
- 表观遗传调节为未来的IA遗传和治疗研究提供了一个有希望的途径.
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