与非血液性恶性瘤相关的血管炎.
1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Medical Oncology Department, Istanbul, Turkey.
Current opinion in rheumatology
|December 4, 2025
概括
血管炎可能是潜在癌症的信号,也可能是由免疫检查点抑制剂 (ICI) 等癌症治疗引起的. 对于这两种情况,早期识别和管理至关重要.
科学领域:
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 非血液性恶性瘤和血管炎之间的关系是复杂的.
- 瘤性血管炎呈现多样,在一些血管炎患者中增加了癌症风险.
- 用于固体瘤的免疫检查点抑制剂 (ICI) 可以诱导血管炎.
研究的目的:
- 审查血管炎和非血液性恶性瘤之间的复杂关联.
- 讨论由免疫检查点抑制剂 (ICI) 诱导的血管炎.
主要方法:
- 关于瘤性血管炎和ICI诱导的血管炎的文献综述.
- 对临床表现,时间和与固体瘤的关联进行分析.
主要成果:
- 血管炎与固体瘤相比,与血液性恶性瘤相比,较少见.
- 皮肤白细胞结晶性血管炎是最常见的副瘤类型,通常与肺部,尿道或胃肠道瘤有关.
- 由ICI引起的血管炎可以影响各种血管大小和位置,包括大血管,中枢神经系统和小血管.
结论:
- 对血管炎患者的警监测有助于早期发现癌症,并指导癌症特异性治疗.
- 及时识别ICI诱导的血管炎对于治疗调整至关重要 (停止ICI,启动免疫抑制剂),以防止严重的并发症.
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