在人口层面的分析中,肠道微生物组调解了富含黄胺的饮食与MASLD之间的关联
William Bell1,2, Amy Jennings1, Nicola P Bondonno1,3,4
1Co-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.
European journal of nutrition
|December 4, 2025
概括
富含黄胺的饮食与与代谢功能障碍相关的脂肪性肝病 (MASLD) 的几率降低有关. 肠道细菌艾森伯吉拉 (Eisenbergiella) 可能部分解释了这种保护作用,突出了肠道微生物群.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 富含黄类的饮食有望预防与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 肠道微生物组在代谢黄酸盐中的作用及其在饮食-MASLD关系中的潜在调解需要研究.
研究的目的:
- 为了研究富含黄类素的饮食与MASLD之间的关联.
- 探索肠道微生物组在这种协会中的调解作用.
主要方法:
- 对531名参与者的横截面分析.
- 使用FlavoDiet得分 (FDS) 评估的黄类素摄入量.
- 通过磁共振成像进行MASLD诊断;统计分析包括多变量逻辑和线性回归,以及使用16S rRNA基因测序数据进行中介分析.
主要成果:
- FDS的翻倍与MASLD的几率下降27%相关 (OR:0.73;P=0.04).
- 艾森伯吉拉属的丰度介导了这一关联的9.2% (间接效应β=-0.006;P=0.04).
结论:
- 富含黄胺的饮食与改善肝脏健康有关.
- 肠道细菌Eisenbergiella可能部分调解富含黄胺的饮食对MASLD的保护作用.
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K


