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使用人类iPSC衍生的膜间歇细胞构建一个三维状动脉疾病模型

Ruikang Guo1,2, Zhen Qi1,2, Ping Qiu1

  • 1Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.

Stem cell reviews and reports
|December 4, 2025
PubMed
概括

人类诱导的多能干细胞衍生的膜间歇细胞 (hiVICs) 由于FOXO1活性,在2D培养物中不会化. 使用hiVICs的3D模型成功复制了性大动脉膜疾病 (CAVD) 的矿化.

关键词:
3D组织构造构造 3D组织构造动脉的疾病 动脉疾病这就是FOXO1的意义.诱导的多能干细胞干细胞甲胺是一种甲胺.膜间歇细胞 膜间歇细胞

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