胃节律和胃食道逆流之间的关联通过同时测绘身体表面的胃和24小时的pH测试来定义
William Xu1,2, Sam Simmonds2, Daphne Foong2,3
1Department of Surgery, University of Auckland, Auckland, New Zealand.
概括
胃食道逆流病 (GERD) 患者表现出不稳定的胃电活动,与更严重的症状和酸暴露有关. 这种胃节律不稳定可能表明GERD中神经肌肉功能障碍.
科学领域:
- 胃肠病学 胃肠病学
- 神经胃肠病学 神经胃肠病学
- 医疗器械 医疗器械
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种普遍的疾病,通常抗拒医疗治疗.
- 胃肌电功能异常被怀疑是导致GERD病变的原因.
- 了解胃电活动和反流事件之间的关系对于改善GERD管理至关重要.
研究的目的:
- 调查通过体表胃映射 (胃精度) 测量的肌电异常与通过24小时pH测试评估的反流事件之间的相关性.
- 为了确定胃肌电功能障碍是否与GERD症状严重程度有关.
- 探索胃精度节律指数 (GA-RI) 作为胃神经肌肉功能障碍在GERD中的生物标志物的潜力.
主要方法:
- 一项前性观察性研究涉及40名受试者 (20名GERD患者,8名非GERD症状患者,20名对照).
- 同时测量胃肌电活动,使用胃精度和24小时食道pH测试.
- 标准化4.5小时胃精度测试与验证的症状记录,数据分为15分钟的时代.
主要成果:
- 与对照组相比,患有GERD的患者的胃节律稳定性 (GA-RI) 显著降低 (P=0.011).
- 较低的GA-RI与食道酸暴露的增加有关 (DeMeester评分;r=-0.46,P=0.042).
- 胃节律不稳定与恶心增加 (r=-0.22) 和过度腹 (r=-0.28) 相相关,但与胃灼热严重程度或反流事件没有直接关联.
结论:
- 用GA-RI测量的胃节律不稳定与GERD患者的症状严重程度增加和整体酸暴露有关.
- 在GERD中,GA-RI作为同时发生的胃神经肌肉功能障碍的潜在新兴生物标志物.
- 虽然与胃灼热没有直接联系,但节律不稳定暂时与恶心和腹等消化不良症状有关.
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