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美国儿童和青少年的预后营养指数和喘之间的关联:一个横截面研究
Xiaolan Zhang1, Ning Feng2, Linjun Du1
1Department of Pediatrics, Third People's Hospital of Liaocheng, Liaocheng, Shandong, China.
较高的预后营养指数 (PNI) 水平与儿科人口中喘风险降低有关. 43.40或更高的PNI显示有保护作用,这表明PNI具有保护作用.
科学领域:
- 儿科肺病学 儿科肺病学
- 营养免疫学 营养免疫学
- 流行病学 流行病学
背景情况:
- 喘是儿童和青少年常见的慢性呼吸道疾病.
- 根据预后营养指数 (PNI) 评估的营养状况可能会影响喘的发展和进展.
- 了解PNI和喘风险之间的关系对于确定潜在的预防策略至关重要.
研究的目的:
- 调查PNI与儿童和青少年喘风险之间的独立关联.
- 为了确定PNI对喘风险的潜在值影响.
- 探索PNI在儿科喘中的保护作用.
主要方法:
- 来自NHANES (2003-2020) 的11,196名参与者 (<20岁) 的横截面分析.
- 基于问卷数据的喘诊断;使用白蛋白和淋巴细胞计数计算PNI.
- 使用加权多变量逻辑回归,受限立方线和两阶段回归模型来评估关联和非线性关系.
主要成果:
- 在PNI和喘风险之间观察到显著的反向关联 (OR=0.963).
- 在最高PNI三位数的参与者表现出与最低三位数 (OR=0.659) 相比,喘风险降低了34%.
- 确定了一种非线性反向L形关系,在PNI≥43.40 (OR=0.93) 时具有保护值效应.
结论:
- 增加PNI水平与儿童群体的喘风险降低有关.
- 43.40的PNI值表明儿童和青少年对喘有保护作用.
- 需要进一步的研究来阐明机制,并探索PNI作为儿科喘预测生物标志物的潜力.
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