维生素A:对肌肉健康的生物学功能和影响
Chen-Lu Chang1, Jia-Wen Li1, Zheng-Kai Shen2
1Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Nutrition reviews
|December 4, 2025
概括
维生素A通过其代谢物全转录氨酸 (ATRA) 对于骨肌肉健康至关重要. 这篇评论探讨了它在肌肉修复,新陈代谢和肌肉疾病的潜在治疗用途中的作用.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 骨肌疾病对全球健康造成重大负担,需要新的治疗策略.
- 维生素A传统上以视力和免疫力中的作用而闻名.
- 新出现的证据强调了维生素A在骨肌肉生理学中的作用.
研究的目的:
- 审查维生素A对骨肌肉健康的影响机制.
- 探索维生素A在肌肉细胞增殖,分化,修复和再生中的作用.
- 检查维生素A对抗氧化防御和肌肉能量代谢的影响.
主要方法:
- 对维生素A和骨肌肉现有研究的文献综述.
- 在肌肉生物学中研究全转网红酸 (ATRA) 的研究分析.
- 综合了关于维生素A生理和治疗作用的发现.
主要成果:
- 维生素A,特别是ATRA,调节关键的肌肉过程,包括增殖,分化和再生.
- 亚特拉会影响骨肌中的抗氧化剂防御机制.
- 维生素A影响骨肌肉的能量代谢.
结论:
- 维生素A在维持骨肌肉健康方面发挥着多方面的作用.
- 了解ATRA的机制为治疗骨肌疾病的新疗法提供了潜力.
- 进一步研究维生素A对肌肉疾病的治疗应用是有必要的.
相关概念视频
Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
The Functions of the Skeletal System
5.6K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
5.6K
Exercise and Muscle Performance
2.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.3K
Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K


