世界贸易中心的老年响应者中的多药性和脆弱性
Chinmayi Venkatram1, Fred Ko2,3, Ghalib Bello4
1Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
PloS one
|December 4, 2025
概括
多药和增加跌倒风险的药物使用在老年世界贸易中心 (WTC) 应急人员中很常见. 优化药物管理对于这个暴露于环境危害的人群健康老龄化至关重要.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 临床药房 临床药房
背景情况:
- 世界贸易中心 (WTC) 应急人员在9/11恢复工作期间面临环境危险.
- 这些暴露可能会加速老龄化,并增加这个人群的脆弱性.
- 了解药物风险对于WTC应急人员的长期健康至关重要.
研究的目的:
- 检查多药和衰老WTC响应者的脆弱性之间的关系.
- 为了确定与多药和降低风险增加药物 (FRID) 使用相关的因素.
- 在这个群体中,为减轻与药物相关风险的策略提供信息.
主要方法:
- 该研究包括来自2017-2019年WTC健康计划数据的50岁以上WTC受访者.
- 使用WTC特定的临床脆弱性指数评估的脆弱性.
- 多变量逻辑回归分析了与多药 (≥5种药物) 和FRID使用的关联,并对共变量进行调整.
主要成果:
- 在6,966名WTC受访者中,55%使用多药;7.6%使用FRID.
- 虚弱与多药 (OR 1.15) 和FRID使用 (OR 1.11) 独立相关.
- 老年,肥胖,保护性服务工作,GERD,阻塞性呼吸道疾病和上呼吸道疾病与更高的多药制药几率有关. 女性的性行为,吸烟,焦虑,抑郁和PTSD与更高的FRID使用率有关.
结论:
- 在老年WTC响应者中观察到多药和FRID使用的高患病率.
- 脆弱性与多药和FRID使用显著相关.
- 优化药物管理对于促进WTC响应者健康老龄化至关重要.
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