截然不同的转录因子相互作用驱动前列腺癌不同阶段的HOXB13活性
Betul Ersoy-Fazlioglu1,2, Shreyas Lingadahalli3, Umut Berkay Altintas3
1Koç University Research Center for Translational Medicine, Istanbul 34450, Türkiye.
概括
HOXB13对于前列腺癌 (PCa) 的生长至关重要,即使在缺乏雄激素受体 (AR) 的瘤中也是如此. 这项研究显示了HOXB13的存在.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- HOXB13是前列腺癌 (PCa) 发病和进展的关键转录因子.
- 大多数研究将HOXB13与雄激素受体 (AR) 活性联系起来,但其在AR阴性PCa中的作用不明.
研究的目的:
- 调查HOXB13在AR阳性和AR阴性PCa中的作用.
- 阐明不同PCa亚型中HOXB13作用的独特机制.
- 在AR阴性PCa中识别HOXB13的关键相互作用伙伴.
主要方法:
- 在AR阳性和AR阴性PCa模型中对HOXB13表达的分析.
- 在AR阴性瘤中研究HOXB13与AP-1和SMARCD2的相互作用.
- 染色体可访问性测试用于研究HOXB13/SMARCD2复杂功能.
主要成果:
- 在AR阳性和AR阴性PCa模型中,HOXB13对于扩散至关重要.
- HOXB13对前列腺组织具有很高的选择性.
- 在AR阴性PCa中,HOXB13与AP-1相互作用,改变其囊胞体和相互作用体.
- 该SMARCD2蛋白调解HOXB13活性,修改染色质的可访问性,并促进AR阴性PCa的增殖.
结论:
- HOXB13在AR阴性割耐性前列腺癌中发挥着关键作用.
- HOXB13利用不同的机制,包括与SMARCD2的相互作用,来推动AR阴性PCa的扩散.
- 这项研究强调HOXB13作为晚期前列腺癌的潜在治疗点.
更多相关视频
相关概念视频
01:30General Transcription Factors
6.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.7K
02:23Master Transcription Regulators
7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
02:23Master Transcription Regulators
2.7K
2.7K
02:16Transcription Factors
82.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.2K
02:33Combinatorial Gene Control
9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
02:36RNA Polymerase II Accessory Proteins
10.7K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
10.7K