消化管高分辨率测量可以安全有效地进行,同时使用类似葡萄糖素的-1受体激动剂
Khushboo Gala1, Preeyati Chopra1, Ashwariya Ohri1
1Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
概括
类似葡萄糖-1受体激动剂 (GLP-1RAs) 不会显著影响食道高分辨率计量 (HRM) 的可行性或安全性. 这项研究发现,在HRM手术期间使用GLP-1RA和对照剂的患者中,不耐受率相似.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 食道高分辨率计量 (HRM) 对于诊断食道运动障碍至关重要.
- 在肥胖和2型糖尿病中,越来越多地使用类似葡萄糖-1受体激活剂 (GLP-1RAs),这引起了人们对其对HRM程序的影响的担忧,原因是胃排空延迟.
- 患者的不耐受性可能会限制HRM的有效性.
研究的目的:
- 评估食道高分辨率计量 (HRM) 的耐受性和安全性,目前正在使用类似葡萄糖素的-1受体激活剂 (GLP-1RAs) 的患者.
- 确定GLP-1RA的使用是否会影响HRM程序的可行性和并发症率.
主要方法:
- 进行了一项追溯病例控制研究,涉及接受HRM的成年患者.
- 在HRM期间服用GLP-1RA的患者被确定为病例 (n=83),与非GLP-1RA的对照匹配 (n=83).
- 排除标准包括先前存在的胃肠道动力障碍,先前前肠道手术,食道阻塞,大间歇性,恶性瘤或最近的阿片类药物使用.
主要成果:
- 在166名患者中,15名 (9.0%) 患有不耐受性导致的不完整HRM,GLP-1RA使用者 (10.84%) 和对照组 (7.2%) 之间没有显著差异.
- 年轻的年龄,球体感觉,消化不良和抑郁症与不完整的HRM有关.
- 在这两组中都没有报告任何不良事件,包括渴望,HRM在停药前的持续时间相似.
结论:
- 类似葡萄糖-1受体激活剂 (GLP-1RA) 的使用似乎不会增加食道高分辨率计量 (HRM) 期间不耐受或不良事件的风险.
- 对于服用GLP-1RAs的患者来说,HRM仍然是一个可行的和安全的程序.
- 诸如年轻的年龄和特定的症状,如球状和消化不良等因素比GLP-1RA使用更能预测HRM不耐受.
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