双特异性抗体治疗血液恶性瘤的门诊治疗:一本实用指南
Kian J Rahbari1, Raul Del Toro Mijares2, Kathryn Kennedy3
1Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN.
JCO oncology practice
|December 4, 2025
概括
双特异性抗体 (BsAbs) 可以安全地在门诊中使用. 从CAR-T疗法和专业方案中吸取的经验教训使患者获得更好的治疗机会,并降低了血液性恶性瘤治疗的成本.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双特异性抗体 (BsAbs) 通过将T细胞与瘤细胞联系起来来治疗血液性恶性瘤.
- 由BsAbs引起的T细胞过活化会导致细胞因子释放综合征 (CRS) 和免疫效应细胞介导的神经毒性综合征 (ICANS).
- 目前的做法要求在CRS和ICANS高风险时期住院监测.
研究的目的:
- 评估对双特异性抗体的门诊治疗的可行性和安全性.
- 确定改善患者获取和降低与BsAb治疗相关的医疗保健成本的策略.
- 调整从门诊化学抗原受体T细胞 (CAR-T) 治疗中学到的经验教训,以适应BsAb的管理.
主要方法:
- 对临床试验经验和BsAb管理的新兴实践的审查.
- 从门诊CAR-T治疗方案中获得的知识的应用.
- 开发专业的多学科团队方法和强大的基础设施.
主要成果:
- 门诊提供BsAbs是可行的.
- 需要一个专业的多学科团队,明确的程序和大量的患者支持.
- 预防性抗炎疗法和修改剂量计划提高了安全性.
结论:
- 可以实现对BSAbs的门诊治疗.
- 这种方法需要一个全面的支持系统和专门的协议.
- 成功的门诊管理可以改善获得和减少BsAb治疗的医疗保健费用.
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