相关实验视频
Updated: Jan 9, 2026

23:53
Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
8.4K
过去和未来的承诺 - 基因疗法和实现未来期望
Eva Hilberg1, Aleksandra Stelmach2, Tineke Kleinhout-Vliek3
1The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
Social science & medicine (1982)
|December 4, 2025
概括
基因疗法为罕见疾病提供了新的希望,但媒体报道往往忽视了诸如高成本和不确定的长期影响等挑战. 对媒体叙述的批判性看法揭示了未来主义承诺与基因治疗可访问性和安全性的当前现实之间的差距.
科学领域:
- 生物技术和遗传医学 生物技术和遗传医学
- 医学伦理与健康政策
- 科学沟通和媒体研究科学传播和媒体研究
背景情况:
- 基因疗法 (例如,Zolgensma,Libmeldy,Luxturna) 代表了治疗罕见遗传疾病的范式转变.
- 人类基因组项目的完成推动了对个性化医学和向基因治疗的期望.
- 媒体叙述经常强调基因疗法的革命性潜力,影响患者和公众的期望.
研究的目的:
- 分析从2020年1月到2023年4月的基因治疗的媒体报道.
- 将当前的基因治疗期望 (安全性,有效性,利能力,可访问性) 与人类基因组项目提出的期望进行比较.
- 识别理想化的叙述与基因疗法实施的现实挑战之间的差异.
主要方法:
- 2020年1月1日至2023年4月30日期间发表的报纸文章的内容分析.
- 对围绕基因治疗进展的媒体话语的定性评估.
- 媒体描绘的期望与基因治疗中记录的挑战进行比较.
主要成果:
- 媒体报道经常强调基因治疗的变革性承诺,经常忽视关键问题.
- 重要的挑战包括成本过高,长期结果不确定,以及可访问性障碍.
- 关于利能力的讨论往往忽略了与基因疗法开发相关的现实世界业务失败.
结论:
- 当前媒体对基因疗法的叙述往往呈现出过于乐观的观点,与实际挑战脱而出.
- 解决成本,可访问性和长期有效性的问题对于对基因治疗影响的现实理解至关重要.
- 需要更平衡的媒体描述来管理期望,并指导对遗传医学未来的知情公共话语.
相关概念视频
Gene Therapy
27.3K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.3K
Microorganisms in Medicine and Therapeutics
917
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
917
What is Genetic Engineering?
79.6K
Overview
79.6K
Humanistic Therapy
306
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
306
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Methods of Nuclear Reprogramming
2.1K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.1K

