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一种层次的核心纳米混合体,用于对Botrytis cinerea的双刺激反应性抗真菌药物

Qi Sun¹, Jian Zeng², Miaomiao Ma²

¹College of Life Sciences, Chongqing Normal University, Chongqing 401331, China; Animal Biology Key Laboratoryof Chongqing Education Commission of China, Chongqing 401331, China.

Colloids and surfaces. B, Biointerfaces

|December 4, 2025

概括

一个新的微/纳米系统 (CMC@Eu-ZIF@ZnO) 提供了针对植物病原体的精确抗真菌药物. 这一可持续战略增强了作物保护,减少了对环境的影响.

科学领域:

农业科学农业科学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

植物病原菌对农业构成重大威胁,需要先进的,环保的控制方法.
传统的杀菌剂面临的挑战包括不稳定性,非目标效应和有限的响应能力.

研究的目的:

设计一个层次化的微/纳米系统,用于精确地输送抗真菌剂.
为了利用真菌毒性机制,以有针对性和按需释放药物.
开发一种可持续的替代传统农业化学品作物保护的替代品.

主要方法:

一个双核心外微/纳米系统 (CMC@Eu-ZIF@ZnO) 的制造,其中有ZnO核心,ZIF-8外和CMC涂层.
整合pH和细胞酶触发的释放机制,以响应真菌活动.
评估Eu和ZnO纳米颗粒的协同抗真菌作用.
在植物疾病模型上评估降雨性,植物毒性和疗效.

主要成果:

该系统证明了pH和细胞酶触发的释放,在双重刺激下达到91.5%的累积释放.
在大豆发芽试验中观察到高雨速保留率 (67.9%) 和可以忽略的植物毒性.
在番茄叶上的病变得到了有效的控制,显示出强大的抗真菌活性.
Eu和ZnO纳米颗粒的协同作用增强了真菌中的膜破坏和氧化应激.

结论:

开发的微环境响应的层次交付平台克服了传统杀菌剂的局限性.
这种纳米结构集成提供了一个可持续和精确的方法,用于环保的作物保护.
该研究强调了先进纳米材料在开发下一代农业解决方案方面的潜力.

关键词:

这是一种抗真菌药物.这种植物是Botrytis cinerea.核心外微球是核心外的微球.尤金诺醇是一种刺激响应释放的释放.

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