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Updated: Jan 9, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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在慢性髓性白血病细胞中,ATTEC介导的BCR-ABL降解

Zhiyan Wang1, Tingting Xu2, Yiying Che2

  • 1Department of Molecular Pharmacology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China; State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China.

European journal of medicinal chemistry
|December 4, 2025
PubMed
概括

新的自细胞结合基因组 (ATTECs) 在慢性髓性白血病 (CML) 细胞中有效降解BCR-ABLcoprotein. 这种有针对性的方法为下一代CML疗法提供了一个有希望的策略.

关键词:
自基因组结合的仿真体 (ATTECs)在 BCR-ABL 基蛋白上.慢性髓性白血病 (CML) 是一种疾病.达沙替尼布 (Dasatinib) 是一种GW5074 GW5074 的使用情况

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