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当代美国PRRSV 1-4-4 L1C.5孤立导致严重疾病,与历史高度致病性PRRSV相比

Jayne E Wiarda¹, Bailey Arruda¹, Tavis K Anderson¹

¹Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA.

|December 4, 2025

概括

一种高度毒性的猪生殖和呼吸系统综合征病毒 (PRRSV) 菌株,L1C.5,在美国特有,导致疾病严重程度相当于历史的亚洲高度致病性PRRSV (HP-PRRSV). 了解共享的毒性因素是控制这些猪威胁的关键.

科学领域:

兽医病毒学兽医病毒学
猪病流行病学猪病流行病学
动物病理学动物病理学

背景情况:

猪生殖和呼吸系统综合征病毒 (PRRSV) 对全球猪业构成重大经济和动物健康挑战.
高毒性PRRSV菌株,包括当代美国分离物和历史的亚洲菌株,对大量的发病率和死亡率负责.
有效的控制策略受到PRRSV菌株不断变化的性质和变化的致病性阻碍.

研究的目的:

为了比较当代美国PRRSV L1C.5隔离的病原性和疾病动力学,与中度毒性美国菌株 (MN184) 和高度病原性亚洲菌株 (JXwn06) 相比.
为了评估临床症状,病毒载荷,免疫反应,以及由不同的PRRSV菌株在断奶猪中诱导的病理变化.
为了确定各种高度致病性PRRSV菌株之间的共同毒性特征.

主要方法:

断奶的猪被接种了PRRSV JXwn06,L1C.5,MN184或模拟对照.
动物在规定的时间间隔 (2,6,10天注射后) 或发生严重疾病时进行尸检.
临床指标,病毒量化,细胞因子和抗体水平,以及毛细/组织病理性病变被评估并在各组之间进行比较.

主要成果:

与MN184和模拟组相比,接种PRRSV JXwn06和L1C.5的猪表现出明显更严重的临床疾病和病理结果.
疾病的进展和严重程度在JXwn06和L1C.5感染组之间非常相似.
病毒载量和炎症性细胞因子概况表明JXwn06和L1C.5组的致病性增加.

结论:

一种当代的美国PRRSV菌株 (L1C.5) 的致病性与历史上毁灭性的亚洲高度致病性PRRSV (HP-PRRSV) 菌株 (JXwn06) 的致病性相当.
尽管基因和地理来源不同,但这些菌株具有共同的毒性特征,导致严重的疾病.
识别导致高毒性的共同分子和病理特征对于制定针对性控制措施来应对北美当前和新兴的PRRSV威胁至关重要.

关键词:

一四四四是什么意思在 L1C.5 中.PRRSVV 在这个问题上.致病性致病性致病性猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪生殖和呼吸系统综合征病毒猪猪的猪猪的猪猪的猪猪的猪

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