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前端对面网络介导加速iTBS和cTBS的抗抑郁作用:TMS-EEG研究

Xianwei Che¹, Haoyang Zhao², Xinyi Ye²

¹Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China; Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.

Cell reports. Medicine

|December 4, 2025

概括

加速间歇和连续的提达突发刺激 (a-iTBS和a-cTBS) 通过正常化大脑活动有效治疗抑郁症. 这些疗法调节皮层刺激性和网络功能,为治疗机制提供了新的见解.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗工程医疗工程

背景情况:

耐治疗抑郁症 (TRD) 是一个重大的临床挑战.
加速间歇和连续的甲爆刺激 (a-iTBS和a-cTBS) 是有效的TRD治疗方法.
这些刺激技术的潜在神经机制尚未完全理解.

研究的目的:

在TRD中研究a-iTBS和a-cTBS的神经机制.
为了比较a-iTBS和a-cTBS对皮质刺激性和网络功能的影响.
确定与抗抑郁药疗效相关的生物标志物.

主要方法:

使用了同时进行的跨磁刺激 (TMS) 和脑电图 (TMS-EEG).
该研究包括40名TRD患者和40名健康对照 (HC).
基线和刺激后的TMS-EEG数据分析了皮质刺激性和网络传播.

主要成果:

TRD患者在皮质刺激性 (左侧低活性,右侧消抑制) 中表现出基线异常.
a-iTBS使左侧刺激正常化,而a-cTBS使右侧抑制正常化,使两者达到HC水平.
两种类型的刺激都调节了前侧双网络活动,特别是涉及左下侧双叶 (IPL),其效果与抗抑郁药物结果相关.

结论:

在TRD中,a-iTBS和a-cTBS使异常皮质刺激正常化.
这些疗法调节前端对象电路,具有与抗抑郁药物反应相关的特定网络效应.
这些发现为优化基于TMS的抑郁症治疗提供了机械洞察力.

关键词:

这就是TMS-EEG.下面的头顶叶片下面的头顶叶片泰达爆发刺激的刺激.治疗耐药性抑郁症治疗耐药性抑郁症

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