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使用生理学基础的药理动力学模型预测纳米颗粒的体内行为:建模方法和问题

Jingyu Wang1, Xiaoqian Xie1, Xuewei Cao1

  • 1Department of Pharmaceutics, School of Pharmacy, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|December 4, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型越来越多地用于纳米粒子研究. 本综述详细介绍了纳米粒子的PBPK建模策略,突出了与小分子药物的差异,并提出了应对现有挑战的解决方案.

关键词:
淋巴循环的淋巴循环.单核细胞系统是一个单核细胞系统.纳米颗粒是如何形成的在PBPK模型中,透率系数 透率系数药理动力学 药理动力学组织与血分区系数.

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