多糖类作为纳米颗粒对生物受体的活性向剂的潜力:一篇综述
Jessica Cavalcante Martins1, Mylena Karolina Oliveira do Amaral1, Izabel Maria de Melo Amaral1
1National Institute of Science and Technology of the Economic and Industrial Health Complex, Department of Pharmaceutical Sciences, Federal University of Pernambuco-UFPE, Brazil.
International journal of biological macromolecules
|December 4, 2025
概括
多糖类通过与生物受体相互作用,增强纳米颗粒的向药物输送. 本综述强调了用于稳定和响应性纳米系统的氨酸和其他生物聚合物,从而推动了临床转化.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 多糖提供生物相容性和生物降解性.
- 它们允许纳米粒子功能化用于活性药物向.
- 与生物受体的相互作用是关键.
研究的目的:
- 审查聚糖功能化纳米颗粒 (NP) 用于药物向.
- 分析与特定生物受体的相互作用.
- 评估临床翻译的潜力和挑战.
主要方法:
- 来自Web of Science和Scopus (2020-2025) 的30项研究的综合性审查.
- 对多糖配体及其向受体的分析.
- 评价结合类型 (共价与非共价) 和它们的影响.
主要成果:
- 氨酸向CD44是最常见的.
- 莱万,富科伊丹和普鲁兰也表现出高度的亲和力.
- 共价债券确保稳定性;非共价债券提供响应性.
结论:
- 多糖对于设计有选择性和有效的纳米系统至关重要.
- 挑战包括标准化,扩展和临床使用监管.
- 需要进一步的研究来克服治疗应用的这些障碍.
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