查检测到男性腹腔大动脉动脉瘤和同步癌症
Anton Axelsson1, Antti Siika2, Mareia Talvitie2
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
概括
被诊断为腹腔大动脉动脉瘤 (AAA) 的男性患癌率更高,存活率更差,特别是活跃吸烟者. 这凸显了对AAA患者进行向癌症查的必要性.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 在65岁的男性中,以人口为基础的腹腔大动脉瘤 (AAA) 查降低了死亡率.
- 与一般人群相比,患有AAA的男性患心血管疾病和癌症的死亡率增加.
研究的目的:
- 为了确定被诊断为AAA的男性癌症的患病率.
- 评估AAA癌症患者的动脉瘤进展情况.
- 为了比较患有AAA,有癌症和没有癌症的男性的生存率.
主要方法:
- 在斯德哥尔摩,2010年至2024年期间诊断出AAA的男性的基于人口的纵向研究.
- 数据来自计算机化的区域AAA查数据库和医院登记处收集的数据.
- 平均随访时间为7.2年.
主要成果:
- 在被诊断患有AAA的1,151名男性中,24.6% (283) 被诊断患有癌症.
- 动脉瘤直径在无癌症患者中最小,在肺癌患者中最大.
- 癌症患者的五年生存率 (79.2%) 与没有癌症患者 (94.7%) 相比显著较低,特别是活跃吸烟者.
结论:
- 癌症及其治疗可能会影响AAA的自然史.
- 在患有癌症的AAA患者中,尤其是活跃吸烟者中,死亡率升高令人担忧.
- 考虑加强癌症查和潜在的修改AAA治疗时间在这个小组是合理的.
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