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在上皮细胞中对胆固醇感应的重编程支持胰腺炎症

Giulia Milan1, Olga A Mareninova2, Marco Fantuz1

  • 1Veneto Institute of Molecular Medicine (VIMM), Padova, Italy; Department of Biology, University of Padova, Padova, Italy.

Molecular metabolism
|December 4, 2025
PubMed
概括

炎症会通过降低尼曼-皮克C型蛋白1 (NPC1) 的调节,导致胰腺细胞中的胆固醇积累. 这种胆固醇的积累驱动了胰腺状细胞的转化,这是胰腺炎的一个关键事件.

关键词:
向导管形质变形症 (ADM) 是一种向导管形质变形症.胆固醇 胆固醇 胆固醇lysosome 是一个溶解体.胰腺炎是一种胰腺炎.在 mTORC1 的情况下,mTORC1 是

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