在自限性中出现异常的动态连接模式,带有中尖的自限性.
Xu Chen1, Linfeng Song1, Jiaren Zhang1
1Department of Radiology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Huichuang District, Zunyi, Guizhou, China.
Brain research bulletin
|December 4, 2025
概括
患有自限性与中尖峰 (SeLECTS) 的儿童表现出大脑网络动态的改变,特别是注意力网络的连接性降低. 这些发现表明激发-抑制不平衡,并提供了关于SELECTS的功能重组的见解.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 医疗成像医学成像
背景情况:
- 带有中尖的自我限制性 (SeLECTS) 是一个常见的儿童综合征.
- 了解SELECTS的神经基础对于开发有针对性的干预措施至关重要.
- 动态功能网络连接 (dFNC) 为研究中大脑功能提供了一种新的方法.
研究的目的:
- 用SELECTS对儿童进行dFNC模式的特征.
- 为了确定与SELECTS相关的神经调节和功能障碍的异常.
- 探索dFNC变化与认知功能之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 数据来自61名接受SELECTS治疗的儿童和69名健康对照人群.
- 分析使用独立组件分析 (ICA),滑动窗口方法和隐藏的马尔科夫建模 (HMM) 来评估dFNC.
- 在SELECTS和HC组之间比较dFNC属性.
主要成果:
- 确定了四个不同的dFNC状态,SELECTS和HC之间的连接模式存在显著差异.
- 有SELECTS的儿童在各州的背部注意网络 (DAN) 中显示出减少的连接性.
- 在SELECTS中,DAN和视觉网络 (VIS) 之间的功能连接的时间变异性减少,与智力相关.
结论:
- 在接受SELECTS的儿童中观察到异常的动态大脑网络连接模式.
- 这些异常可能表明神经网络中潜在的激发抑制不平衡.
- 这些发现提供了关于SELECTS中大脑功能重组和神经生物学机制的见解.
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