母亲从大米中产生的产前暴露及其与新生儿神经行为发育的关联
Chunfang Gan1, Xinbin Feng2, Kun-Lin Yang3
1State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China; University of the Chinese Academy of Sciences, Beijing 101408, China; School of Public Health and Health & Ministry of Education Key Laboratory of Environmental Pollution and Disease Monitoring, Guiyang, Guizhou Medical University, Guiyang 561113, China.
Environmental pollution (Barking, Essex : 1987)
|December 4, 2025
概括
米中的甲基 (MeHg) 与婴儿的神经发育风险有关. 这项研究发现矿区大米中MeHg含量较高,与婴儿神经行为障碍相关,并为早期检测提供了预测工具.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 甲基 (MeHg) 是一个全球性的环境毒素.
- 米消费对神经发育构成风险,特别是在鱼类摄入量较低的人群中.
- 关于来自大米的MeHg暴露和神经发育结果的流行病学数据有限.
研究的目的:
- 在母婴队列中调查通过大米消费暴露的MeHg与神经行为发育障碍 (NBDI) 之间的关联.
- 为了确定环境和生物样本中的MeHg暴露水平.
- 为与MeHg相关的NBDI开发预测模型.
主要方法:
- 一项母婴队列研究 (420对) 在中国的矿区进行.
- 测量了米饭,胎盘和带血液中的MeHg水平.
- 用多阶段物流回归,受限立方线,LightGBM和SHAP模型来分析关联并预测NBDI风险.
主要成果:
- 与对照区域 (1.09 ng/g) 相比,来自暴露于的地区的米的MeHg水平显著更高 (5.07 ng/g).
- 环境介质和人口样本中的MeHg暴露与NBDI发生率呈正相关性.
- 胎盘MeHg暴露与NBDI显著相关 (OR = 1.23),显示了剂量-反应关系.
- 对于与MeHg相关的NBDI,LightGBM模型实现了高预测性能 (AUC=0.91).
结论:
- 来自大米的MeHg暴露与新生儿的神经行为发育障碍有关.
- 胎盘MeHg度是NBDI的一个关键预测因素.
- 开发的预测模型为识别有风险的婴儿提供了临床应用.
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