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在大学生中基于正念减轻压力的抑郁减轻效应的基础的神经机制:RS-fMRI研究

Xiaonan Zhan¹, Huibiao Li², Ke Chen²

¹The First Clinical Medical College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350004 China; Key Laboratory of Orthopedics & Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian,350000 China.

Biological psychology

|December 4, 2025

概括

基于正念的压力减轻 (MBSR) 通过改变大脑活动,有效地减少了大学生的抑郁症. 这项干预措施降低了与情绪调节相关的右侧中 cingulate 皮质 (MCC) 网络中的活动和连接性.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
心理健康心理健康

背景情况:

抑郁症是全球重要的健康问题,尤其在大学生中普遍存在.
基于正念的压力减轻 (MBSR) 显示了减轻抑郁症状的希望,但其神经生物学基础需要进一步调查.

研究的目的:

研究MBSR在大学生中的抗抑郁作用的神经生物学机制.
通过静止状态功能磁共振成像 (rs-fMRI) 检查神经活动和功能连接的变化.

主要方法:

一项随机对照试验涉及42名健康的大学生,他们被分配到为期8周的MBSR干预或对照组.
rs-fMRI用于评估大脑活动 (ALFF,fALFF,ReHo) 和功能连接.
抑郁症症状使用抑郁焦虑压力尺度-21.21进行测量.

主要成果:

与对照组相比,MBSR参与者在抑郁症得分上显示出显著的改善.
MBSR导致右中环状皮层 (MCC) 的ALFF,fALFF和ReHo减少.
在MBSR组中观察到右MCC与海马体和前体之间的功能连接性下降,与抑郁症改善负相关.

结论:

MBSR促进了与情绪调节和自我参考处理相关的大脑区域的适应性神经重组.
研究结果表明,MBSR提高了神经效率,为亚临床人群的抗抑郁作用提供了机械洞察力.

关键词:

阿尔弗,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫.抑郁症抑郁症抑郁症美国FC FC FC 这里是ReHoHo的房间.法尔夫夫夫 (法尔夫夫夫) 的意思 rs-fMRI 是一个

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