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基于胆固醇和乳酸脱酶的七个标准的准确性,用于区分输出性和输出性多叶流液
Su-Na Cha1,2,3, Yan Niu4, Jian-Xun Wen4
1Center for Clinical Epidemiology Research, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Scientific reports
|December 4, 2025
概括
使用肺液胆固醇和乳酸脱酶 (LDH) 水平的新标准显示,准确度与莱特在区分肺排泄物和转排泄物方面的标准相当.
科学领域:
- 肺部病理学 肺部病理学
- 临床化学 临床化学
- 诊断的准确性 诊断的准确性
背景情况:
- 目前用于排列多流的诊断标准依赖于胆固醇和乳酸脱酶 (LDH) 水平,但缺乏广泛的验证和比较分析.
- 之前的研究还没有直接比较同一患者群体内的各种基于胆固醇和LDH的诊断标准的诊断性能.
研究的目的:
- 评估和比较基于多液胆固醇和LDH水平的既定和新标准的诊断准确性,以区分多排泄物和转化物.
- 用接收器运行特征 (ROC) 曲线来评估个体膜液胆固醇和LDH水平的性能.
主要方法:
- 对回顾性 (BUFF) 和前性 (SIMPLE) 队列的分析,包括患有肺部溢液的患者.
- 使用肺部活检,微生物培养和细胞学验证出血原因.
- 通过ROC曲线评估诊断准确性,并将以前报告的7个胆固醇/LDH标准与莱特标准进行比较.
主要成果:
- 腹液胆固醇和LDH水平在排泄物中明显升高,而不是转化物.
- 在结合的队列中,液胆固醇的ROC曲线下的面积 (AUC) 为0.90和LDH为0.87.
- 综合标准 (胆固醇> 1.04 mmol/L或LDH> 0.6x ULN) 显示了与莱特标准相比的诊断准确性.
结论:
- 胸腔液胆固醇和LDH水平是区分胸腔排泄物和转化物的有价值生物标志物.
- 胸腔液胆固醇和LDH值的特定组合提供了类似于广泛使用的莱特标准的诊断准确性.
- 这一验证的标准为流的分类提供了可靠的替代方案.
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