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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K
Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

7.8K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
7.8K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.0K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
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相关实验视频

Updated: Jan 9, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Published on: December 7, 2021

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LimbNET:用于模拟肢体发育中的基因网络空间模式的协作平台.

Antoni Matyjaszkiewicz1,2, James Sharpe3,4,5

  • 1European Molecular Biology Laboratory, EMBL Barcelona, C/ del Dr. Aiguader 88, PRBB Building, Barcelona, 08003, Spain. antoni.matyjaszkiewicz@embl.es.

Molecular systems biology
|December 4, 2025
PubMed
概括
此摘要是机器生成的。

LimbNET是一个新的网络工具,用于模拟肢体发育. 它允许研究人员共享和测试基因调控网络模型,整合实验数据以获得更好的生物学见解.

关键词:
计算机建模 计算建模基因监管网络 基因监管网络林布发展 林布发展在线社区平台 在线社区平台模式形成 模式形成

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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
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Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

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科学领域:

  • 发展生物学 发展生物学
  • 计算生物学 计算生物学
  • 系统生物学 系统生物学

背景情况:

  • 计算建模对于理解复杂的生物系统至关重要.
  • 研究人员之间分享模型和假设对于科学进步至关重要.
  • 肢体的发育涉及复杂的时空模式,需要先进的建模工具.

研究的目的:

  • 介绍LimbNET,这是一个在线平台,用于建模,模拟和可视化肢体发育中的时空模式.
  • 促进在研究界内无共享基因调控网络 (GRN) 模型和假设.
  • 在发育生物学中弥合实验数据和计算模拟之间的差距.

主要方法:

  • 林布NET使远程用户能够定义和模拟任意的二维基因调节网络 (GRN) 模型.
  • 现有模型的数据库允许用户探索和扩展以前的工作.
  • 基于图像的基因表达数据被标准化并集成到建模框架中,以便与模拟输出进行直接比较.

主要成果:

  • LimbNET为研究人员提供了一个共同的框架来测试和比较假设.
  • 该平台集成了空间时间基因表达数据,使实验数据和模拟结果之间的直接比较成为可能.
  • 参数优化关闭了实验和模拟之间的反循环.

结论:

  • 肢体网络 (LimbNET) 加强了肢体发展研究中的合作和知识共享.
  • 该工具通过无需特殊软件,通过Web浏览器访问,使图像驱动的建模民主化.
  • 它通过计算建模为理解发展过程提供了更完整的方法.