相关实验视频

Updated: Jan 9, 2026

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

改善子宫内膜微生物群对体外受精结果的影响

Masachi Hanaoka¹, Kanako Hanaoka², Mayu Yamada²

¹Hanaoka IVF Clinic Shinagawa, Gatecity Osaki East Tower 1 F, Osaki 1-11-2, Shinagwa-Ku, Tokyo, 141-0032, Japan. hanaokamasachi@gmail.com.

Journal of assisted reproduction and genetics

|December 4, 2025

概括

在体外受精 (IVF) 患者中恢复健康的子宫微生物群,其中乳酸菌占主导地位,可以改善妊娠结果. 特定的Lactobacillus物种影响成功,有针对性的治疗提供生殖益处.

科学领域:

生殖医学生殖医学
微生物组研究微生物组研究
遗传学是一个遗传学.

背景情况:

子宫微生物组在生殖健康和怀孕成功方面发挥着至关重要的作用.
子宫内膜微生物组的失调或失衡越来越多地与不孕症和体外受精 (IVF) 的不良结果有关.
乳酸菌种是健康的阴道和子宫环境的关键组成部分,但它们在试管婴儿结果中的特定作用需要进一步阐明.

研究的目的:

用下一代测序 (NGS) 来分析IVF患者的子宫微生物组合.
调查乳杆菌物种,特别是乳杆菌内置物对怀孕结果的影响.
评估抗生素治疗在调节子宫内膜微生物组和提高试管婴儿成功率方面的疗效.

主要方法:

对257名试管婴儿患者进行了子宫内膜微生物组测试.
根据Lactobacillus spp.患者被分类为乳杆菌主导微生物组 (LDM) 和非LDM组. 它们的丰富性 (>90%).
非LDM患者接受了治疗,并且在治疗后组中分析了那些显示改善的患者.

主要成果:

乳酸菌在许多试管婴儿患者中占主导地位,但有些人表现出与细菌性阴道炎相关的细菌.
治疗改善了81.4%的非LDM患者的微生物组,导致怀孕成功率与LDM组相似.
乳杆菌crispatus和乳杆菌gasseri与积极的妊娠结果有关,而高丰度的乳杆菌iners (≥74.2%) 与较低的成功率相关.

结论:

在非LDM试管婴儿患者中恢复LDM可以增强子宫内膜微生物组合和妊娠结果.
乳酸菌的特定物种对于试管婴儿的成功至关重要;高水平的乳酸菌与减少怀孕率有关.
有针对性的微生物干预措施有望改善试管婴儿患者的生殖结果.

关键词:

牛乳杆菌的内置者乳杆菌占主导地位的微生物群 (LDM)16S 核糖体RNA 的 16S 核糖体RNA.辅助生殖技术是一种辅助生殖技术.宫内膜的微生物组是什么

更多相关视频

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

相关概念视频

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...