夜班工作和乳腺癌:从病因学到精确风险分析
Silvia Vivarelli1, Tania Formica2, Ylenia Puliatti2
1Department of Biomedical and Dental Sciences, Morphological and Functional Imaging, Section of Occupational Medicine, University of Messina, Messina, Italy. silvia.vivarelli@unime.it.
NPJ breast cancer
|December 4, 2025
概括
夜班工作 (NSW) 与女性由于昼夜干扰而增加乳腺癌 (BC) 风险有关. 该审查整合了生物机制,生物标志物和流行病学数据,以更好地评估和预防风险.
科学领域:
- 职业健康 职业健康 职业健康
- 癌症流行病学 癌症流行病学
- 时间生物学 时间生物学
背景情况:
- 夜班工作 (NSW) 是与乳腺癌 (BC) 风险相关的日益严重的公共卫生问题.
- 国际癌症研究机构将新南威尔士州归类为可能的人类致癌物,主要是由于夜间暴露于光线的昼夜干扰.
研究的目的:
- 审查将新南威尔士州与英属哥伦比亚省连接的生物机制.
- 探索用于早期BC检测和轮班工人风险分析的新生物标志物.
- 综合流行病学证据,分析夜班女工的BC风险.
主要方法:
- 对生物途径的审查:黑激素抑制,氧化应激,炎症,表观遗传变化等等.
- 对BC风险分层的潜在生物标志物的识别.
- 对流行病学研究 (病例控制,队列) 的分析,考虑混因素和暴露错误分类.
主要成果:
- 多种生物机制表明新州和BC发展之间存在联系.
- 新兴的生物标志物可能有助于早期检测和个性化风险评估.
- 流行病学数据显示异质性,但强调了与新南威尔士州相关的潜在BC风险.
结论:
- 整合机理学,分子学和流行病学数据对于理解新南威尔士州和英属哥伦比亚省之间的关系至关重要.
- 综合方法支持精准医学,以改善夜班工作者的风险分层和有针对性的预防策略.
- 这项研究为高危人群的职业健康政策和预防措施提供了信息.
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