对过高甘油三血症引起的急性胰腺炎的固定剂量胰岛素方案的评估:一项回顾性队列研究
Neden Yacine1, Stephanie Chauv1, Melissa R Peng1
1Department of Pharmacy, Intermountain Medical Center, Murray, Utah, USA.
一种新的固定剂量胰岛素方案用于高甘油三血症引起的急性胰腺炎 (HTG-AP) 显示出与标准护理相似的有效性. 这种管理HTG-AP的标准化方法是安全的,可以在不同的医院环境中复制.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 过高甘油血症引起的急性胰腺炎 (HTG-AP) 是一种严重的疾病,需要立即降低甘油三.
- 目前的管理策略各不相同,这凸显了对标准化治疗方案的需求.
研究的目的:
- 评估HTG-AP的标准化固定剂量胰岛素滴滴协议的安全性和有效性.
- 为了比较胰岛素协议的前协议和后协议实施之间的临床结果和安全概况.
主要方法:
- 一项多中心回顾性队列研究,涉及466名患有HTG-AP的成年患者.
- 根据协议实施日期,患者被分为协议前 (n=242) 和协议后 (n=224) 组.
- 主要结局是ICU停留时间;次要结局包括住院时间,降低甘油三的时间和安全事件 (低血糖,低血糖).
主要成果:
- 两组之间在ICU停留时间,住院时间或降低甘油三的时间上没有显著差异.
- 在治疗后组中,轻度低血糖更频繁 (36.6%对25.2%,p=0.008).
- 严重低血糖和低血糖的发病率很低,在治疗前和治疗后的组之间是可比的.
结论:
- 对HTG-AP的标准化固定剂量胰岛素方案显示了与历史护理相似的临床结果.
- 该方案具有可接受的安全性,严重低血糖和低血糖的发病率较低.
- 这种标准化协议为在各种住院环境中管理HTG-AP提供了一种可重复的方法.
更多相关视频
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
04:14Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
相关概念视频
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Collaborative Care
Assessment:
Dipeptidyl Peptidase 4 Inhibitors
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
