偏头痛中的表观遗传学:初级编辑委员会成员的愿景
Damiana Scuteri1, Alejandro Labastida-Ramirez2,3, Eloisa Rubio-Beltran4
1Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy. damiana.scuteri@unicz.it.
The journal of headache and pain
|December 4, 2025
概括
表观遗传修饰,包括DNA甲基化和microRNAs,影响偏头痛慢性化和治疗反应. 了解这些表观遗传机制是个性化偏头痛治疗和改善患者治疗结果的关键.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 偏头痛是年轻女性残疾的主要原因,许多患者经历了治疗阻力.
- 尽管有诸如色素基因相关 (CGRP) 疗法等进展,但40%的患者仍然难以治疗.
- 环境因素和表观遗传修饰对偏头痛病原和治疗反应的影响尚未得到充分研究.
研究的目的:
- 研究表观遗传机制在偏头痛病理生理学中的作用.
- 探索表观遗传因素如何导致偏头痛特征的差异.
- 分析表观遗传学对患者对偏头痛治疗反应的影响.
主要方法:
- 对偏头痛表观遗传修饰研究的系统文献综述.
- 在PubMed,Scopus和Web of Science数据库中进行了搜索.
- 包括从数据库创建到2025年10月2日的研究.
主要成果:
- DNA甲基化变化与偏头痛慢性化有关,影响突触可塑性和雌激素受体信号传递的基因.
- 循环中的microRNAs (miRNAs) 在偏头痛中表达变化,可以通过像 gepants 这样的治疗来调节.
- 表观遗传修饰影响过渡受体潜能 (TRP) 通道 (TRPV1,TRPA1) 并与预防性药物的作用 (酸,托皮拉) 以及对单克隆抗体 (erenumab) 的反应有关.
结论:
- 与CGRP,突触可塑性和TRP通道相关的基因的表观遗传修饰在偏头痛中至关重要.
- 需要进一步研究表观遗传学,以了解偏头痛病理生理学和神经药理学.
- 针对表观遗传机制的个性化医疗方法可以提高偏头痛治疗的有效性和安全性.
相关概念视频
Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
X-linked Traits
58.2K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.2K
Genomic Imprinting and Inheritance
36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K
Chromosomal Theory of Inheritance
59.5K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
59.5K


