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开发和验证用于预测肺癌和乳腺癌中无脑转移存活率的诺姆图

Bo Wang¹, Tianjiao Fu^2,3, Hengyu Zhao⁴

¹Department of Radiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, No. 2999 Jinshan Road, Xiamen, 361000, China.

Cancer imaging : the official publication of the International Cancer Imaging Society

|December 4, 2025

概括

这项研究确定了肺癌和乳腺癌患者脑转移的关键风险因素. 开发了预测性诺姆图,以评估无脑转移的存活率,以帮助临床决策.

科学领域:

在瘤学瘤学.
医学统计医学统计

背景情况:

初级肺癌 (LC) 和乳腺癌 (BC) 经常转移到大脑 (BM).
识别BM的风险因素对于改善患者的治疗结果至关重要.

研究的目的:

在患有初级LC或BC的患者中识别大脑转移无生存的独立风险因素.
开发和验证BM发展的预测性名ograms.

主要方法:

对1739名LC和1150名BC患者的回顾性分析.
单变量和多变量考克斯回归用于识别风险因素.
使用C指数和校准曲线开发和验证名ograms.

主要成果:

对于LC,病态阶段,N阶段,向治疗和化疗与BM有关.
对于BC,三阴性乳腺癌 (TNBC),Ki-67指数,向治疗,放射治疗和手术是重要的因素.
纳米图表显示出良好的区分能力 (C指数从0.786到0.843).

结论:

在临床上,用于预测LC和BC患者的BM的简单名录成功构建和验证.
这些名图显示出良好的预测性能,可以帮助临床管理.

关键词:

大脑转移是大脑的转移.这个名字叫做Nomogram.原发性乳腺癌是一种主要的乳腺癌.原发性肺癌是一种肺癌.风险预测风险预测

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