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针对复发性或耐火性扩散性大B细胞淋巴瘤的CAR-T疗法的比较经济评估:系统性审查
Tien Hoang Tran1, Hyung Seok John Kim2
1Department of Practice, Sciences, and Health Outcomes Research, University of Maryland Baltimore, 220 Arch Street, Baltimore, MD, 21201, USA.
PharmacoEconomics
|December 4, 2025
概括
艾克西卡巴丁基可乐塞尔 (axi-cel) 似乎是治疗复发性或耐火性大B细胞淋巴瘤的最具成本效益的仿真抗原受体T细胞疗法. 然而,由于依赖间接比较和有限的全球数据,结果需要仔细解释.
科学领域:
- 血液学 血液学 血液学
- 卫生经济学 卫生经济学
- 在瘤学瘤学.
背景情况:
- 化学抗原受体T细胞 (CAR T) 疗法已经改变了复发性或耐火性大B细胞淋巴瘤 (LBCL) 治疗.
- 由于CAR T疗法的高成本,需要进行经济评估来确定它们的价值.
- 在患有复发性或耐火性LBCL的成年人中,CAR T疗法的比较经济价值仍然不确定.
研究的目的:
- 评估CAR T疗法对复发性或耐火性LBCL的相对成本效益.
- 确定影响这些疗法成本效益结论的关键因素.
主要方法:
- 在Embase,Scopus和PubMed的系统文献搜索 (开始至2025年10月).
- 包括全面的经济评估,将CAR T疗法与复发性或耐火性LBCL进行对比.
- 对人口,模型结构和成本效益的数据提取;使用CHEERS和Drummond检查清单进行评估.
主要成果:
- 包括来自美国,西班牙,法国和日本的八项经济评估.
- 据报道,axicabtagene ciloleucel (axi-cel) 最常见的是具有成本效益 (7/8研究).
- 由于依赖间接比较和缺乏个体患者层面的数据,发现了大量的不确定性.
结论:
- 目前的证据表明,axi-cel可能是复发性或耐火性LBCL最具成本效益的CAR T选择.
- 由于间接比较和缺乏对低至中等收入国家的研究,应该谨慎解释结果.
- 需要进一步的经济评估和临床试验才能得出最终的结论.
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