在健康,无症状的成年人中,近端与远端食道功能的初步表征
Erin L Reedy1,2,3,4,5, Bonnie Martin-Harris4,5,6, Jacob Schauer7
1Department of Otolaryngology - Head & Neck Surgery, University of Rochester, Rochester, New York, USA.
Neurogastroenterology and motility
|December 4, 2025
概括
这项研究使用高分辨率食道测量仪 (HRM) 确定了靠近食道功能的正常值. 结果量化了收缩活力,长度和时间,有助于更全面的食道运动性评估.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 高分辨率食道测量 (HRM) 是食道运动性评估的黄金标准.
- 目前的诊断标准 (芝加哥分类v4.0) 主要关注远端食道功能.
- 需要在HRM中定义近端食道功能的正常值.
研究的目的:
- 为了确定接近食道功能的正常高分辨率食道测量 (HRM) 值.
- 为了评估靠近的食道功能,在仰卧和直立的位置.
- 建立对近端食道收缩性的定量测量.
主要方法:
- 招募健康,无症状的成年人 (≥18岁).
- 使用标准的HRM协议,包括测量近端收缩积分 (PCI),收缩时间和长度.
- 分析数据使用总结统计和配对的t测试来比较仰卧和直立的位置.
主要成果:
- 平均躺卧PCI为423.9mmHg-s-cm (3.2s持续时间,长度为5.5cm).
- 平均直立PCI为183.9mmHg-s-cm (2.2s持续时间,4.5cm长度).
- 在仰卧和直立姿势之间的近端食道功能中观察到显著差异 (p<0.0001).
结论:
- 这些初步数据通过HRM提供了通过HRM初步量化正常的近端食道功能.
- 收缩活力,长度和时间的测量提供了对近端食道运动的洞察力.
- 这项工作代表了将近位食道评估纳入临床HRM解释的基本步骤.
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