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Updated: Jan 9, 2026

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

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跨物种的美特罗尼达药业动力学:整合全米缩放和最小生理学基础的药业动力学建模的元分析

Fatma Kir1,2, William J Jusko3

  • 1Pharmacometrics Group, A2-Ai LLC, 2723 S. State Street, Suite 310, Ann Arbor, Michigan, 48104, USA.

The AAPS journal
|December 4, 2025
PubMed
概括

这项研究模拟了跨物种的甲尼达 (MTZ) 药理动力学,使用了以生理学为基础的全米最小PK模型. 结果显示一致的MTZ配置,与体重相称的清除和高生物可用性.

关键词:
测量尺度缩放 (allometric scaling) 是指所有米尺度缩放的方法.获得许可证的时间.这种药物是甲尼达.最小的生理学基础的药物动力学建模.药物动力学 药物动力学

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