系统性免疫炎症指数可以在通过直肠超声波引导的前列腺活检之前用于区分良性和恶性病理吗?
Turgay Kacan1, Demirhan Orsan Demir2, Ali Kaan Yildiz2
1Department of Urology, Ankara Bilkent City Hospital, Ankara, 06810, Turkey. turgaykacan@gmail.com.
BMC urology
|December 5, 2025
概括
活检前的系统性免疫炎症指数 (SII) 和其他炎症标志物不能可靠地预测前列腺癌. 然而,SII和血小板/淋巴细胞比率 (PLR) 可能有助于诊断高风险前列腺癌.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 前列腺癌的诊断依赖于前列腺活检.
- 需要前列腺癌组织病理学预测标记.
- 系统性免疫炎症指数 (SII) 是一个潜在的活检前标记.
研究的目的:
- 在前列腺活检之前评估SII的预测能力.
- 评估SII,PLR和NLR,以区分非恶性和恶性前列腺组织.
- 确定这些标记物在不同前列腺癌风险组中的有用性.
主要方法:
- 对1040名接受前列腺活检的患者进行了回顾性分析.
- 活检阴性和前列腺癌组之间的SII,PLR和NLR的比较.
- 统计分析包括ROC曲线分析,以评估诊断性能.
主要成果:
- 活检阴性和所有前列腺癌组之间SII,PLR或NLR没有显著差异.
- 在活检阴性和高风险前列腺癌组之间观察到SII和PLR的显著差异.
- ROC分析显示SII (AUC0.568) 和PLR (AUC0.618) 的诊断性能有限.
结论:
- 活检前的血液炎症参数对于一般前列腺癌检测是不有效的.
- SII和PLR显示出潜在的诊断工具,专门用于高风险的前列腺癌.
- 这些标记物不适合检测低风险和中等风险前列腺癌患者的病理.
相关概念视频
Assessment of the Abdomen I: Inspection and Auscultation
Introduction
The abdominal examination is a cornerstone of clinical medicine, serving as a critical tool in diagnosing various gastrointestinal (GI) diseases. It involves a systematic approach that includes inspection and auscultation, each with distinct yet complementary roles in assessing the abdomen. This article will delve into these two primary methods healthcare professionals use to examine the abdomen.
Inspection of the Abdomen
The first step in any abdominal examination is inspection.
The abdominal examination is a cornerstone of clinical medicine, serving as a critical tool in diagnosing various gastrointestinal (GI) diseases. It involves a systematic approach that includes inspection and auscultation, each with distinct yet complementary roles in assessing the abdomen. This article will delve into these two primary methods healthcare professionals use to examine the abdomen.
Inspection of the Abdomen
The first step in any abdominal examination is inspection.
Assessment of the Rectum and Anus
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):


