更新的性活动和前列腺癌风险的剂量反应元分析
Abouzar Raeisvandi1, Sanaz Omidi1, Massoumeh Javaheri1
1Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
BMC cancer
|December 5, 2025
概括
更高的射精频率可以防止前列腺癌,而大多数其他性行为没有显著的联系. 需要进一步的研究来了解性活动.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 前列腺癌是一个重大的健康问题,了解其风险因素对于预防至关重要.
- 以前的研究已经探讨了性活动和前列腺癌之间的联系,但证据需要更新.
- 性行为因素包括性交的频率,伴侣数量,第一次性交的年龄,以及射精/自慰的频率.
研究的目的:
- 系统地审查和分析有关性活动因素与前列腺癌风险之间的关系的现有证据.
- 提供有关特定性行为如何影响患前列腺癌的可能性的最新见解.
主要方法:
- 在主要数据库 (PubMed,科学网,Scopus) 进行了全面的文献搜索,截至2025年10月.
- 包括的研究使用I2统计数据和使用Begg和Egger测试的出版偏差分析了一致性.
- 使用随机效应模型计算了具有95%置信区间的聚合赔率 (OR).
主要成果:
- 对29项研究 (315,193名参与者) 的分析显示,前列腺癌与频繁性交,女性伴侣数量或自慰频率之间没有显著的关联.
- 在第一次性交时的年龄较大显示出与前列腺癌风险的非显著的负相关性.
- 更高的射精频率显示出对前列腺癌的显著保护作用 (OR = 0.83;95% CI:0.77,0.90).
结论:
- 大多数检查的性行为似乎没有显著改变前列腺癌风险.
- 增加射精频率可能会对前列腺癌产生保护作用.
- 前列腺癌是多因素的;进一步的研究是必要的,以充分阐明性活动在预防中的作用.
相关概念视频
01:03Dose-Response Relationship: Overview
4.7K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.7K
01:22Dose-Response Relationship: Potency and Efficacy
6.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.3K
01:25Dose-Response Relationship: Selectivity and Specificity
9.5K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.5K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
382
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
382
01:12Hazard Ratio
549
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
549
01:21Dose Size and Dosing Frequency: Determination Methods
257
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
257