胎儿生物识别和母亲的特征第二个三个月预测死产的预测
Linda Lindström1,2, Olof Stephansson1,3, Sven Cnattingius1
1Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Acta obstetricia et gynecologica Scandinavica
|December 5, 2025
概括
在怀孕中期,小的胎儿股骨长度 (FL) 与小的腹部周长 (AC) 相结合,会增加死产的风险. 然而,目前的孕产妇因素和胎儿测量为死胎的预测提供了很差的预测.
科学领域:
- 产科和妇科 产科和妇科
- 胎儿医学 胎儿医学
- 围产期流行病学 围产期流行病学
背景情况:
- 小小的胎儿尺寸是死胎的主要危险因素.
- 之前的研究没有检查过中期胎儿尺寸测量的组合,以预测死产.
研究的目的:
- 评估怀孕中期的超声波胎儿测量,结合母亲因素,可以预测死产风险.
主要方法:
- 瑞典377,563例单子怀孕的历史队列研究 (2014-2021年).
- 测量了第二个三个月的双对面直径 (BPD),腹周 (AC) 和股骨长度 (FL).
- 计算了相对风险和赔率比率,并开发了一个多变量预测模型.
主要成果:
- 短的第二个三个月的股骨长度 (FL),特别是小腹周长 (AC),显著增加死产的风险.
- 正常的FL与小BPD和/或AC并没有增加死产风险.
- 结合母亲特征,小AC和短FL的预测模型显示出有限的预测性能 (所有死胎的AUC为0.623).
结论:
- 短FL,特别是小AC,与死亡出生风险的增加有关.
- 母亲特征和妊娠中期胎儿生物识别对死胎的预测价值不佳.
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