在中国的一个队列中,对母体血清脂质及其与不良结果的关联进行三季度特定的参考间隔
Jiangtao Hu1, Bo Peng2,3,4, Li Lin1
1Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing, China.
概括
确定孕妇血液脂质的三个月具体参考间隔 (TSRI) 对于识别失脂症至关重要. 偏离这些TSRI与不良妊娠结果 (APO) 有着显著的联系,这突显了监测脂质配置文件的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 临床化学 临床化学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 怀孕期间的失脂症会增加妊娠期糖尿病,孕前和不良周产期结果的风险.
- 这些脂质变化可能会影响母亲和儿童的长期健康.
- 目前关于正常妊娠脂质范围的缺乏共识,需要建立参考间隔.
研究的目的:
- 为了确定产妇血液脂质的三个月具体参考间隔 (TSRI).
- 调查母亲的脂质样本和不良妊娠结果 (APO) 之间的关联.
主要方法:
- 对8950名孕妇的临床数据进行了回顾性分析.
- 脂质测定 (TC,TG,LDL-C,HDL-C) 在三个季度进行.
- 通过使用百分位数方法,根据怀孕前BMI分层建立TSRI.
- 后勤回归分析,以评估脂质配置文件和APO之间的关系.
主要成果:
- 脂质概况在三个月内显示出显著的变化,并受到怀孕前的BMI的影响.
- 为体重不足,正常体重和超重/肥胖群体建立了季度特定参考间隔 (TSRI).
- 升高的TC,TG,LDL-C或降低的HDL-C与增加的APO风险相关.
- 三甘油 (TG) 在所有季度中显示出与APO最强的关联.
结论:
- 建议使用三个月特定的参考间隔 (TSRI) 来准确识别怀孕期间的失脂症.
- 偏离已确立的TSRI与不良妊娠结果有显著的关联.
- 针对TSRI监测母亲的脂质样本对于改善妊娠结果至关重要.
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