一项系统性审查和元分析,检查甲状腺功能过高或甲状腺功能低下与患肝癌的概率之间的关系
Omid Asbaghi1, Ghazaleh Shimi2, Arman Ghorbani2
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC cancer
|December 5, 2025
概括
这次元分析发现,甲状腺功能低下症与队列研究中的肝癌 (LC) 风险有关,但甲状腺功能过高症并非如此. 早期发现甲状腺问题可能有助于预防肝癌.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
背景情况:
- 观察性研究显示,关于甲状腺功能障碍和肝癌 (LC) 风险的结果是相互矛盾的.
- 甲状腺功能障碍包括甲状腺功能下降 (甲状腺功能下降) 和甲状腺功能过高 (甲状腺功能过高).
- 了解这些关联对于肝脏致癌研究至关重要.
研究的目的:
- 系统地审查和元分析甲状腺功能障碍与LC风险之间的关系.
- 探索甲状腺功能障碍对肝癌发展的潜在临床影响.
主要方法:
- 在PubMed/Medline,ISI,Web of Science和Scopus数据库中搜索到2025年3月.
- 使用固定和随机效应模型计算效应大小和95%置信区间 (CI).
- 包括5项观察性研究,参与者超过320万.
主要成果:
- 甲状腺功能低下症在队列研究中与LC风险增加显著相关 (综合效果大小:1.45,95%CI:1.08-1.95,P=0.012).
- 在病例控制研究中,甲状腺功能低下症和LC风险之间没有发现显著的关联 (组合效果大小:1.31,95%CI:0.68-2.49,P=0.413).
- 甲状腺功能障碍与LC风险没有显著关联 (综合效果大小:1.10,95%CI:0.90-1.34,P=0.337).
结论:
- 甲状腺功能低下症与肝癌的风险增加有关,特别明显在队列研究中.
- 甲状腺功能障碍似乎与肝癌风险无关.
- 甲状腺功能障碍,特别是甲状腺功能低下症,可能会通过代谢和荷尔蒙途径影响肝癌发生,这表明早期治疗对有风险的人来说很重要.
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